Cardiotoxicity explores how certain cancer therapies have been shown to cause an increased risk of cardiac cell damage and symptomatic heart failure. Perhaps the most common cardiotoxic effect is left ventricular (LV) dysfunction, mainly associated with the application of anthracyclines and trastuzumab.1
Earlier diagnosis of damage enhances the opportunities to accommodate cardioprotective treatment while continuing the cancer treatment.
Cardiotoxicity explores how certain cancer therapies have been shown to cause an increased risk of cardiac cell damage and symptomatic heart failure. Perhaps the most common cardiotoxic effect is left ventricular (LV) dysfunction, mainly associated with the application of anthracyclines and trastuzumab.1
Earlier diagnosis of damage enhances the opportunities to accommodate cardioprotective treatment while continuing the cancer treatment.
Managing the risk of cardiotoxicity takes cooperation between cardiologists and oncologists; ideally starting with a baseline cardiac assessment of patients scheduled to receive potentially cardiotoxic agents.4
However, the simple and widely available assessment of left-ventricular ejection fraction (LVEF) by 2D echochardiography often fails to detect the small changes in LV contractility. More accurate measurements are available from 3DEF. But it is global longitudinal strain (GLS) that completes either analysis, as the optimal parameter of deformation for the early detection of subclinical LV dysfunction.4
Dynamic HeartModelA.I. and AutoStrain provide valuable insights to support cardiovascular monitoring and cardiotoxicity prevention, in close collaboration with oncologists and hematologists.
Dr Teresa López Fernández
Cardiac Imaging and Cardio-Oncology Unit Leader, La Paz University Hospital, Madrid, Spain
Cardiology quantification designed to increase confidence
Philips Dynamic HeartModelA.I. is a 3D tool that provides robust, reproducible ejection fraction (EF) in seconds as part of a routine workflow.
* Compared to the general population
** Anatomical Intelligence