Physiology

Proven outcomes.1,2,3
Superior value.
1,3

iFR is in a class of its own

iFR is the leading hyperemia-free physiologic index for measuring pressure in diagnostic and interventional procedures. Only offered by Philips, iFR is an evidence-based methodology that improves outcomes, saves time, and reduces patient discomfort.1,2,3 iFR Co-registration maps the physiologic measurements, directly onto the angiogram enabling more complete procedural guidance.

iFR is recognized in key industry guidelines

 

  • Only iFR has been included in both the AUC (ACC Appropriate Use Criteria)4 and NCDR (National Cardiovascular Data Registry).5
  • Only iFR has been designated as “definitely beneficial” by SCAI (Society of Cardiac Angiography and Interventions).6
  • Only iFR has received a Class 1A designation in the ESC (European Society of Cardiology) guidelines.7

Only iFR has clinically validated patient outcome data in the largest physiology studies ever

Proven outcomes

  • Validated in more than 4,500 patients1,2
  • Consistent outcomes as with FFR1,2
  • 0.89 cut-point backed by data1,2,8
Define flair graph

Superior value 

  • 10% cost saving per patient3
  • 10% reduction in procedure time1,2
  • 90% reduction in patient discomfort1
iFR icons
Define flair graph

Proven outcomes

  • Validated in more than 4,500 patients1,2
  • Consistent outcomes as with FFR1,2
  • 0.89 cut-point backed by data1,2,8
iFR icons

Superior value 

  • 10% cost saving per patient3
  • 10% reduction in procedure time1,2
  • 90% reduction in patient discomfort1
How do you know where to treat?
How do you know where to treat?
iFR co-registration still
Play

DEFINE PCI

Unseen focal lesions cause residual ischemia10
iFR icons
LAD deferral is safer with iFR9
iFR icons

DEFINE PCI

Unseen focal lesions cause residual ischemia10
iFR icons
LAD deferral is safer with iFR9
iFR icons
Introducing IntraSight

Introducing IntraSight
Smart. Simple. Seamless.

Introducing the all-new Philips IntraSight interventional applications platform where imaging, physiology, co-registration11 and software come together to facilitate optimal patient care. IntraSight offers a comprehensive suite of clinically proven modalities, such as, iFR/FFR, IVUS and co-registration11 to simplify complex interventions, speed routine procedures and provide improved patient care.

Only iFR has co-registration for advanced physiologic guidance

Map iFR values directly onto the angiogram, so you can see precisely which parts of a vessel are causing ischemia

 

  • Mapping of physiologic pressure drops onto the angiogram to better discern focal, serial or diffuse disease.
  • Precise lesion severity, location and length assessment.
  • Make length measurements without a cumbersome pull back device.
  • Physiologic impact of a virtual stent.
  • Plan your procedure with physiologic guidance.
Available on the new Philips IntraSight interventional applications platform and as an upgrade to the Core systems.

Why should you use iFR Co-registration?

Improving PCI with
iFR Co-registration

Dr. Justin Davies explains how iFR Co-registration can identify disease location and the likely impact of PCI before you stent.
Dr. Davies video
Play

Transforming how we do PCI with
iFR Co-registration

Dr. Allen Jeremias explains the need to understand not just whether there is ischemia, but where it is when planning for PCI.
Dr. Jeremias
Play

DEFINE PCI results

1 in 4 patients leave the cath lab with post-PCI residual ischemia, mostly due to unseen focal lesions.10
1 in 4 icon

Experts discuss DEFINE PCI key findings

Watch Drs. Allen Jeremias, Gregg Stone, Habib Samady and Manesh Patel as they discuss the results of DEFINE PCI.
Definie PCI key findings

Why should you use iFR Co-registration?

Dr. Davies video
Play

Improving PCI with iFR Co-registration

Dr. Justin Davies explains how iFR Co-registration can identify disease location and the likely impact of PCI before you stent.
Dr. Jeremias
Play

Transforming how we do PCI with iFR Co-registration

Dr. Allen Jeremias explains the need to understand not just whether there is ischemia, but where it is when planning for PCI
1 in 4 icon

DEFINE PCI results

1 in 4 patients leave the cath lab with post-PCI residual ischemia, mostly due to unseen focal lesions.10
Definie PCI key findings

Experts discuss DEFINE PCI key findings

Watch Drs. Allen Jeremias, Gregg Stone, Habib Samady and Manesh Patel as they discuss the results of DEFINE PCI.

Where should 
we treat?

Click on a letter to visually identify physiologically significant lesions
Angio answer image
Angio answer image
That is not the physiologically significant lesion.
Angio answer image
Correct, that is the physiologically significant lesion.

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1. Davies JE, et al., DEFINE-FLAIR: A Multi- Centre, Prospective, International, Randomized, Blinded Comparison of Clinical Outcomes and Cost Efficiencies of iFR and FFR Decision-Making for Physiological Guided Coronary Revascularization. New England Journal of Medicine, epub March 18, 2017.

2. Gotberg M, et al., Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve Guided Intervention (IFR-SWEDEHEART): A Multicenter, Prospective, Registry-Based Randomized Clinical Trial. New England Journal of Medicine, epub March 18, 2017.

3. Patel M. “Cost-effectiveness of instantaneous wave-Free Ratio (iFR) compared with Fractional Flow Reserve (FFR) to guide coronary revascularization decision-making.” Late-breaking Clinical Trial presentation at ACC on March 10, 2018.  

4. Patel M, et al., ACC/AATS/AHA/ASE/ASNC/SCAI/SCCT/STS 2017 Appropriate Use Criteria for Coronary Revascularization in Patients with Stable Ischemic Heart Disease. J Am Coll Cardiol. 2017 May 2;69(17):2212-2241.

5. ACC CathPCI Hospital Registry.

6. Lofti A, et al. Focused update of expert consensus statement: Use of invasive assessments of coronary physiology and structure: A position statement of the society of cardiac angiography and interventions. Catheter Cardiovasc Interv. 2018;1–12.

7. 2018 ESC/EACTS Guidelines on myocardial revascularization: The task force on myocardial revascularization of the European society of cardiology (ESC) and European association for cardio-thoracic surgery (EACTS). Eur Heart J. 2018;00:1-96.

8. An iFR cut-point of 0.89 matches best with an FFR ischemic cut-point of 0.80 with a specificity of 87.8% and sensitivity of 73.0%. (From ADVISE II, and iFR Operator’s Manual 505-0101.23.

9. Sen S, Ahmad Y, et al. Major Adverse Cardiac Events when an LAD lesion is deferred after physiological assessment by FFR or iFR: A sub-study of DEFINE FLAIR. J Am Coll Cardiol 2019.

10. Jeremias A et al. The DEFINE PCI Trial: Blinded Physiological Assessment of Residual Ischemia after Successful Angiographic Percutaneous Coronary Intervention, presented at ACC 2019.
11. Co-registration tools available within IntraSight 7 configuration via SyncVision