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The significance of slow wave activity (SWA)

Slow wave activity (SWA) during sleep has beneficial effects on the restoration of cognitive function during the day. 

It has been shown that memory consolidation and learning capacity during waking hours are positively influenced by achieving slow wave sleep at night.


Research findings:

 

  • The length and the strength of slow waves matter
  • Intervention during slow wave sleep can enhance slow wave activity
  • Acoustic stimulation found to be an effective way to increase SWA

Acoustic stimulation found to be effective at increasing slow wave activity

Once investigated, acoustic stimulation, or sound, was found to be an effective way to enhance slow waves. 

Additionally, waves enhanced by sound were similar to those spontaneously generated slow waves observed during natural sleep††.


†† Tononi G, Riedner B, Hulse B, Ferrarelli F, Sarasso S. Enhancing sleep slow waves with natural stimuli. Medicamundi. 2010;54(2):82-88.

SmartSleep: Setting the tone for the future of sleep

Philips has developed a closed-loop, EEG-based wearable system (SmartSleep) that uses highly sensitive sensors to detect deep sleep in real time.

The system uses auditory stimulation to enhance slow wave sleep without causing arousals.

 

SmartSleep is for patients who are mildly sleep-restricted, but do not suffer from serious sleep conditions such as insomnia or obstructive sleep apnea †.

Developed in collaboration with Physicians and researchers

 

SmartSleep was founded in 10 years of sleep research by industry leading experts and supported by four years of Philips research and development. Since its inception, Philips has worked closely with a scientific advisory board made up of world-renown sleep physicians and scientists. These experts have played a vital role in SmartSleep’s end-to-end innovation, advising Philips development teams on the science behind the functionality, as well as the design and analysis of experimental trials of SmartSleep in the laboratory and in the home.  

Scientific advisory board

David P. White, MD

Board leader


Philips Chief Scientific Officer and Professor at Harvard Medical School

Eve Van Cauter, PhD

Board member


Professor; Department of Medicine - Section of Endocrinology, Diabetes and Metabolism; Committee on Molecular Metabolism; Committee of Clinical and Translational Science at University of Chicago

David Dinges, PhD

Board member

 

Professor and Chief, Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania

Thomas Roth, PhD

Board member

 

Director of Sleep Disorders and Research Center at Henry Ford Hospital

Robert Stickgold, PhD

Board member

 

Associate Professor of Psychiatry and Director, Center for Sleep and Cognition, Harvard Medical School

Giulio Tononi, MD, PhD

Board member

 

Professor, Director of the Wisconsin Institute for Sleep and Consciousness, University of Wisconsin – Madison School of Medicine

Phyllis Zee, MD, PhD

Board member

 

Chief of Sleep Medicine in the Department of Neurology, Northwestern University Feinberg School of Medicine

In fact, the need for and approach to developing SmartSleep was primarily born from extensive research by Dr. Giulio Tononi showing that sleep slow waves can be enhanced by the delivery of auditory stimuli. His 2010 paper was a critical catalyst in the conceptualization of SmartSleep as an innovative device to use tonal stimulation to improve deep sleep quality in those who do not get enough sleep due to lifestyle.

 

At Philips, we see an opportunity to leverage advanced technology, coupled with scientific and consumer insights, to deliver solutions that improve people’s health and drive differentiated outcomes across the health continuum. Our scientific advisory board and the guidance they offer allow us to continue to improve lives through meaningful innovation that is truly rooted in science.

 

*Serving on Philips Scientific Advisory Board does not indicate direct endorsement of this or any Philips product.

Clinical resources

Whitepapers

Journal articles

Gary Garcia Molina et al, 2018, J. Neural. Eng. in press
doi.org/10.1088/1741-2552/aae18f

 

Centers for Disease Control and Prevention. “Effect of Short Sleep on Daily Activities – United States, 2005-2008.” Morbidity and Mortality Weekly Report, vol. 60, no. 8, pp. 239-242, 2011. 
www.cdc.gov/mmwr/preview/mmwrhtml/mm6008a3.htm

 

H. Van Dongen, G. Maislin, J. Mullington, D. Dinges. “The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology from Chronic Sleep Restriction and Total Sleep Deprivation,” Sleep, vol. 26, no. 2, pp. 117-26, 2015 
https://academic.oup.com/sleep/article/26/2/117/2709164/The-Cumulative-Cost-of-Additional-Wakefulness-Dose?searchresult=1

 

G. Tononi, B. Riedner, B. Hulse, F. Ferrarelli, S. Sarasso. “Enhancing Sleep Slow Waves with Natural Stimuli.” Medicamundi, vol. 54, no. 2, pp 82-88, 2010. https://www.researchgate.net/profile/Brad_Hulse/publication/279545240_Enhancing_sleep_slow_waves_with_natural_stimuli/links/56f7567f08ae81582bf2fde2/Enhancing-sleep-slow-waves-with-natural-stimuli.pdf

M. Bellesi,  B. Riedner, G. Garcia-Molina, C. Cirelli, and G. Tononi. “Enhancement of Sleep Slow Waves: Underlying Mechanisms and Practical Consequences,” Front. Syst. Neurosci., vol. 8, pp 1-17, 2014. doi: 10.3389/fnsys.2014.00208.

https://www.frontiersin.org/articles/10.3389/fnsys.2014.00208/full


Institute of Medicine (US) Committee on Sleep Medicine and Research. “Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem.” Washington DC: National Academies Press, 2006. Available from: https://www.ncbi.nlm.nih.gov/books/NBK19960/. doi: 10.17226/11617.


L. Bayer, I. Constantinescu, S. Perrig, J. Vienne, P.P. Vidal, M. Muhlethaler, et al. “Rocking synchronizes brain waves during a short nap.” Curr. Biol., vol. 21, no. 12, pp. R461–R462, 2011. doi: 10.1016/j.cub.2011.05.012. http://www.cell.com/current-biology/pdf/S0960-9822(11)00539-2.pdf

 

H.V. Ngo, T. Martinetz, J. Born, M. Mölle. “Auditory closed-loop stimulation of the sleep slow oscillation enhances memory.” Neuron, vol. 78, no. 3, pp. 545–553, 2013. doi: 10.1016/j.neuron.2013.03.006. http://www.cell.com/neuron/pdf/S0896-6273(13)00230-4.pdf

† SmartSleep should only be used by people who fall asleep within 30 minutes of trying to fall asleep; sleep at least 5 hours straight but less than 7 hours; don’t regularly wake up during the night; don’t use medications or alcohol to fall asleep and do not have hearing loss. Smartsleep is recommended for use for people 40 years of age and under.