Woman using i-neb advanced nebulizer device

Philips Pharma Solutions

A combined focus on device technology and aerosol drug delivery excellence.

Your drug is our number one priority. We offer a range of devices and drug delivery technologies - developed through nearly 40 years of innovation - giving you flexibility to meet both your clinical and financial requirements. If your drug requires unique features or functions, we can work with you to create a custom device to meet your needs.​

 

Our lab services combine the facilities, methods and equipment you can count on to deliver scientifically validated data, with our staff’s deep knowledge of the regulatory process. So you can be sure your drug is optimally performing, and your submission plan is expertly designed.​

Bringing an aerosol drug to market quickly and cost-effectively takes a successful combination of:​

 

  • Clinical efficacy​
  • Testing accuracy​
  • Regulatory expertise
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    Final CEE consent

    Nebulizers  


    The aerosol delivery systems that Philips offers include features that ensure efficient aerosol drug delivery, in simple to use, portable devices. The devices below feature vibrating mesh technology.
    InnoSpire Go

    InnoSpire Go  

     
    • Designed to reduce overall treatment burden ​
    • Treatment in 4 minutes1
    • Unique two-part design ​
    • Built-in rechargeable battery
    I-neb product image

    I-neb  

     
    • Adaptive aerosol delivery to deliver precise and repeatable doses​2
    • Drug specific capability​
    • Black and white screen functionality​
    • Customization options ​

    Unsure which device is right for your drug?

     

    Use our device decision tree to help determine which device can best suit your aerosol drug delivery needs.

    Aerosol services

     

    Our own state-of-the-art, regulatory compliant R&D and lab facilities deliver comprehensive drug and device testing in clinical performance, drug delivery integrity, and data generation for trials and submission. Philips advanced aerosol devices and lab facilities offer pharmaceutical companies an in-depth level of support from every step of the development process - from pre-test to market.

    Aerosol services

    Testing and support in liquid aerosol delivery  

     

    In our state-of-the-art aerosol science laboratory, our scientists provide guidance for the ideal testing needed for clinical trials, regulatory submissions and approvals. Our laboratory capabilities include:

    Staff icon

    Expert, experienced staff  

     

    Our established team of scientists​ have vast experience and expertise in inhalation science, including aerosol testing, analytical, microbiology and regulatory requirements for device and​ drug submissions.

    Facilities icon

    Cutting-edge facilities  


    Our facilities are designed for testing, analytics and microbiology, and precisely controlled for temperature and humidity. We offer a comprehensive range of testing equipment, methods and measurements.

    Quality icon

    Full standards compliance  


    We operate in full compliance to cGLP standards, offering aerosol testing performed to specific device or pharmaceutical regulations, and against validated SOPs/Methods.


    A proven process  


    Our feasibility testing process includes key steps to validate your drug and prepare it for regulatory submission. Our Material Transfer Agreements include strict controls to ensure your compound is handled with confidentiality, protecting your IP while in our control.

    Stage 1  

    Matching device and drug
    We explore and test the suitability of our devices to your drug, to determine which is the appropriate device to meet critical clinical parameters, including particle size, delivery time, dose and drug residual.

    Stage 2  

    Assessing performance
    We assess the performance of the device in simulated breathing conditions to determine the effectiveness of the device in delivering your drug to a patient, including integrity after delivery, particle size, delivered dose and delivery time.

    Stage 3  

    Preparing for submission
    We generate the necessary data required for submission, by conducting quality assurance testing on the device, your drug and our drug delivery test results in stages 1 and 2.

    Setting you up for success

     
    Our aerosol testing laboratory capabilities can benefit your drug product by:

     

    • Helping you to find the right device for your drug to maximize efficacy and speed to market
    • Pre-testing your new chemical entities before launching costly clinical trials
    • Identifying the ideal approach for both testing and data capture for successful regulatory submission
    • Delivering trial results that are precise and reproducible
    • Delivering data at GLP standards, with analytical and technical documentation that support for regulatory submissions
    Lab professional at computer

    See how we support pharmaceutical partners in bringing aerosol drugs to market with life-changing devices. Philips offer devices that are designed to lessen the overall treatment burden for patients.

    Clinically proven mesh from hospital to home

    Aerogen Logo
    Our advanced aerosol delivery products are the only home-use devices featuring Aerogen Vibronic® meshes*, the same unique palladium vibrating mesh technology used in hospital ventilators worldwide to deliver aerosolized medications. The central aperture plate is just 5mm in diameter and is perforated with 1000 precision formed holes, that vibrate at 128,000 times per second, to produce the optimum particle size for deep lung penetration.

    *excluding I-neb

    Mesh nebulizer capabilities in aerosolizing a wide range of novel pharmaceutical formulas  

     

    Mesh devices should be considered as a first choice when looking at inhaled drug delivery. Devices with different modes of operation (active and passive vibrating mesh) are capable of delivering a variety of pharmaceutical formulations with a wide range of physichemical characteristics.

    Mesh Formulations Graph
    Presented by Philips Respironics at ERS, September 3rd-7th 2016. London UK
    Patient testimonial video still

    Patient testimonial


    Meet Anna, a 7 -year old cystic fibrosis patient, who uses the Philips Respironics I-neb AAD system nebulizer to help manage her condition.

    Explore more  

    Sidestream in use

    Philips also offer a wide range of compressor nebulizers and accessories utilizing the proven, high efficiency, SideStream technology.

    InnoSpire Go uses mesh technology

    Learn how the next generation of mesh technology offers several advantages over more traditional drug delivery systems and can provide a vastly improved patient experience.

    Clinical expertise and leadership in Advanced Aerosol Delivery  

       

    Publications

     

    I-neb AAD System

    Domiciliary Experience of the Target Inhalation Mode (TIM) Breathing Maneuver in Patients with Cystic Fibrosis

    Denyer J, Black A, Nikander K, Dyche T, Prince I.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S45-S54

    Mode of Breathing—Tidal or Slow and Deep—through the I-neb Adaptive Aerosol Delivery (AAD) System Affects Lung Deposition of 99mTc-DTPA

    Nikander K, Prince I, Coughlin S, Warren S, Taylor G.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S37-S43

    Evaluation of Patient-Reported Outcomes and Quality of Life with the I-neb AAD System in Patients with Chronic Obstructive Pulmonary Disease

    Goodman N, Morgan M, Nikander K, Hinch S, Coughlin S.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S61-S70

    The Adaptive Aerosol Delivery System in a Telehealth Setting: Patient Acceptance, Performance and Feasibility

    Nikander K, Denyer J, Dodd M, Dyche T, Webb K, Weller P, Stableforth D.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S21-S27

    Evaluation of the Target Inhalation Mode (TIM) Breathing Maneuver in Simulated Nebulizer Therapy in Patients with Cystic Fibrosis

    Denyer J, Prince I, Dixon E, Agent P, Pryor J, Hodson M.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S29-S36

    The Adaptive Aerosol Delivery (AAD) Technology: Past, Present, and Future.

    Denyer J, Dyche T.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S1-S10

    In Vitro Characterization of the I-neb Adaptive Aerosol Delivery (AAD) System

    Hardaker LEA, Hatley RHM.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S11-S20

    The I-neb Adaptive Aerosol Delivery System Enhances Delivery of α1-Antitrypsin with Controlled Inhalation

    Geller DE, Kesser KC.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S55-S59

    OptiChamber Diamond Valved Holding Chamber

     

    In Vitro Characterization of the OptiChamber Diamond Valved Holding Chamber

    Hatley RHM, von Hollen D, Sandell D, Slator L.

    J Aerosol Med Pulm Drug Deliv. 2014; 27(Suppl 1):S24-S36

    Development of Inhaled Pharmaceuticals   

     

    Rethinking the Paradigm for the Development of Inhaled Drugs

    Pritchard J.

    International Journal of Pharmaceuticals. 2015; 496:1069-1072

    Domiciliary Experience of the Target Inhalation Mode (TIM) Breathing Maneuver in Patients with Cystic Fibrosis

    Denyer J, Black A, Nikander K, Dyche T, Prince I.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S45-S54

     

    Evaluation of Patient-Reported Outcomes and Quality of Life with the I-neb AAD System in Patients with Chronic Obstructive Pulmonary Disease

    Goodman N, Morgan M, Nikander K, Hinch S, Coughlin S.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S61-S70

     

    Evaluation of the Target Inhalation Mode (TIM) Breathing Maneuver in Simulated Nebulizer Therapy in Patients with Cystic Fibrosis

    Denyer J, Prince I, Dixon E, Agent P, Pryor J, Hodson M.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S29-S36

     

    In Vitro Characterization of the I-neb Adaptive Aerosol Delivery (AAD) System

    Hardaker LEA, Hatley RHM.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S11-S20

    Mode of Breathing—Tidal or Slow and Deep—through the I-neb Adaptive Aerosol Delivery (AAD) System Affects Lung Deposition of 99mTc-DTPA

    Nikander K, Prince I, Coughlin S, Warren S, Taylor G.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S37-S43

     

    The Adaptive Aerosol Delivery System in a Telehealth Setting: Patient Acceptance, Performance and Feasibility

    Nikander K, Denyer J, Dodd M, Dyche T, Webb K, Weller P, Stableforth D.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S21-S27

     

    The Adaptive Aerosol Delivery (AAD) Technology: Past, Present, and Future.

    Denyer J, Dyche T.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S1-S10

     

    The I-neb Adaptive Aerosol Delivery System Enhances Delivery of α1-Antitrypsin with Controlled Inhalation

    Geller DE, Kesser KC.

    J Aerosol Med Pulm Drug Del. 2010;23(Suppl 1):S55-S59

       

    OptiChamber Diamond Valved Holding Chamber

     

    In Vitro Characterization of the OptiChamber Diamond Valved Holding Chamber

    Hatley RHM, von Hollen D, Sandell D, Slator L.

    J Aerosol Med Pulm Drug Deliv. 2014; 27(Suppl 1):S24-S36

       

    Development of Inhaled Pharmaceuticals   

     

    Rethinking the Paradigm for the Development of Inhaled Drugs

    Pritchard J.

    International Journal of Pharmaceuticals. 2015; 496:1069-1072

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    References

    1 Using 2.5ml Salbutamol

    2 Nominal 0.5ml chamber delivered Salbutamol to filter in the range 534.1-591.5uL